Bioinformatics Scientist III-Remote, USA

Full-time - Senior

Onsite - Aliso Viejo, CA

Ambulatory Health Care Services

About the position

The Bioinformatics Scientist III position at Ambry Genetics involves designing, developing, and maintaining bioinformatics algorithms and pipelines to support automated variant interpretation. This role requires expertise in gene-disease ontologies and high-throughput genetic data analysis, providing an opportunity to work on innovative tools that impact clinical applications. The successful candidate will collaborate with a cross-functional team to drive product improvements and engage in various technical and analytical tasks.

Responsibilities

• Design, develop, and implement scalable bioinformatics algorithms for variant interpretation.
• Maintain bioinformatics pipelines, ensuring accuracy and efficiency in clinical workflows.
• Collaborate with statisticians to validate new methods, including data collection and analysis algorithms.
• Integrate gene-disease ontologies to enhance variant impact predictions.
• Develop custom software and features according to specifications in collaboration with cross-functional teams.
• Lead end-to-end technical solutions from ideation to release, including testing and deployment.
• Monitor processes and troubleshoot issues to enhance pipeline reliability.
• Prepare thorough documentation of algorithms, workflows, and methods for reproducibility.
• Act as a mentor to junior scientists and engineers.

Requirements

• PhD in bioinformatics, computational biology, structural biology, biophysics, biology, computer science, or related discipline with 4+ years of post-doctoral or industrial experience.
• MS in bioinformatics, computational biology, structural biology, biophysics, biology, computer science, or related discipline with 7+ years of industrial experience.
• Proficiency with bioinformatics databases (ClinVar, HGMD, OMIM) and programming languages (Python, R, SQL, bash, Perl, C/C++, Java) in Linux/Unix.
• Skilled in cloud computing (AWS, Azure, Google Cloud), CI/CD (Bamboo, Jenkins), and containerization (Docker).
• Strong knowledge of gene-disease ontologies and bioinformatics software.

Nice-to-haves

• Experience in API development and statistical analysis methods.
• Familiarity with frameworks/tools like PHP, React, Symfony, and Atlassian suite (Jira, Confluence).
• In-depth knowledge of clinical genetics, mutation analysis, and bioinformatics principles.

Benefits

• Medical insurance
• Dental insurance
• Vision insurance
• 401k with a 4% employer match
• Flexible Spending Account (FSA)
• Paid sick leave
• Generous paid time off (PTO) program