About the position
At Avidity Biosciences, we are passionate about the impact of every employee in realizing our vision of improving people's lives by delivering a new class of RNA therapeutics. Avidity is revolutionizing the field of RNA with its proprietary AOCs, which are designed to combine the specificity of monoclonal antibodies with the precision of oligonucleotide therapies to address targets and diseases previously unreachable with existing RNA therapies. If you are a committed, solution-oriented thinker, join us in making a difference and become part of our growing culture that is integrated, collaborative, agile and focused on the needs of patients. Avidity Biosciences, Inc.'s mission is to profoundly improve people's lives by delivering a new class of RNA therapeutics - Antibody Oligonucleotide Conjugates (AOCs). Utilizing its proprietary AOC platform, Avidity demonstrated the first-ever successful targeted delivery of RNA into muscle and is leading the field with clinical development programs for three rare muscle diseases: myotonic dystrophy type 1 (DM1), Duchenne muscular dystrophy (DMD) and facioscapulohumeral muscular dystrophy (FSHD). Avidity is broadening the reach of AOCs with its advancing and expanding pipeline, including programs in cardiology and immunology through internal discovery efforts and key partnerships.
Responsibilities
- Design, synthesis, purification, and analysis of oligonucleotide conjugates.
- Execution of biophysical/biochemical assays to evaluate target binding.
- Effectively collaborate with internal partners to define and meet project goals/timelines.
- Preparation and communication of research results in both oral and written formats.
Requirements
- BS in chemistry, biochemistry, chemical engineering, or related discipline with 1+ years of laboratory experience within academia or industry.
- Experience in the design and preparation of oligonucleotide conjugates.
- Hands-on experience in the purification and analytical methods for proteins, peptides and oligonucleotides (e.g. RP-HPLC, SEC, HIC, SAX, SDS-PAGE).
- Demonstrated knowledge of biochemical/biophysical assays for characterization of binding affinity is preferred (e.g. FP, ELISA, FRET, BLI).
- Demonstrated ability to troubleshoot and solve problems.
- Proven ability to conduct self-directed research and to work effectively in a dynamic environment with a diverse team of co-workers.
- Solid written and oral communication skills, enthusiasm, integrity, self-motivation, strong interpersonal skills, and attention to detail are necessary.
Benefits
- Competitive compensation and benefits, including the opportunity for annual and spot bonuses, stock options, and RSUs.
- 401(k) with an employer match.
- Comprehensive wellness program including coverage for medical, dental, vision, and LTD.
- Four weeks of time off.
- Commitment to learning and development, including a variety of internal programming developed by and for Avidity employees, opportunities for job-specific training offered by industry, and an education reimbursement program.
