About the position
At Avidity Biosciences, we are passionate about the impact of every employee in realizing our vision of improving people's lives by delivering a new class of RNA therapeutics. Avidity is revolutionizing the field of RNA with its proprietary AOCs, which are designed to combine the specificity of monoclonal antibodies with the precision of oligonucleotide therapies to address targets and diseases previously unreachable with existing RNA therapies. If you are a committed, solution-oriented thinker, join us in making a difference and become part of our growing culture that is integrated, collaborative, agile and focused on the needs of patients. As Avidity transitions from late stage clinical to commercial operations, an effective quality control strategy will be critical to ensuring the safety, efficacy and reproducibility of our drug products. To facilitate these efforts, we are seeking a Scientist to join the Analytics group with experience in developing and optimizing robust cell-based assays for later phase clinical programs. The position will also support preclinical development of second-generation AOC therapeutics. This is a unique opportunity and will enable the individual to interact with multiple departments including Chemistry, Biology, and Bioanalytical Sciences. This individual will work in a high-paced matrix environment and must be able to communicate and collaborate between them effectively.
Responsibilities
- Creative and independent assay design skills
- A solid and independent understanding of molecular biology workflows to design and create fluorescence- and luminescent-based cell reporter assays
- Experience with molecular pharmacology principles used to characterize ligand receptor interactions
- Wet-bench efforts towards analytical assay execution and validation
- Method and SOP development, optimization (including DOE), and documentation
- CRO management to support early and late phase GMP release testing
- Hands on experience with cell line development and engineering (viral and/or CRISPR)
- An understanding of FDA regulations related to GMP analytical testing including USP and ICH guidance
- A positive can-do attitude that thrives working as a part of a highly efficient team
Requirements
- A PhD in biology, pharmaceutical sciences, bioengineering, or equivalent
- 1 -2 years of pharmaceutical experience or 3 -5 postdoctoral and industry experience
- Experience with cell and molecular pharmacology and assay development
- Proven ability to thrive and enable success in a cross-functional and collaborative environment
- Excellent communication and interpersonal skills and the ability to facilitate constructive and expedient problem-solving
- Ability to multi-task, manage conflict, and work in a fast-paced environment
Nice-to-haves
- R or python-based data wrangling skills to facilitate data analysis workflows (preferred but not required)
Benefits
- The base salary range for this role is $138,250 - $141,750
- Annual and spot bonuses
- Stock options and RSUs
- 401(k) with an employer match
- Comprehensive wellness program including coverage for medical, dental, vision, and LTD
- Four weeks of time off
- Commitment to learning and development including job-specific training and education reimbursement program
