Senior Research Associate, Genomics

Genmab - Princeton, NJ

Full-time - Mid Level

Princeton, NJ

Professional, Scientific, and Technical Services

About the position

Genmab is seeking a highly motivated Senior Research Associate to join the Clinical Genomics laboratory in the Precision Medicine department. This role focuses on building capabilities for liquid biopsy using circulating tumor DNA (ctDNA) to support analysis of patients from clinical trials. The position requires in-depth knowledge of immunology and cancer biology, along with significant experience in next-generation sequencing on Illumina platforms.

Responsibilities

• Build capabilities for liquid biopsy using circulating tumor DNA (ctDNA) to support analysis of patients from clinical trials.
• Handle human blood plasma, extract DNA/RNA, assess quality of nucleic acids, prepare DNA libraries, and sequence on the Illumina platform.
• Automate methods using in-house Beckman i7/i5 liquid handlers.
• Analyze clinical trial samples from various cancer indications monthly and integrate data with other biomarkers.
• Perform assay validations, periodic quality assessments, and document assays using in-house digital systems (LIMS/ELN).
• Collaborate with the clinical trial operations team for sample management/reporting and the data science group to ensure assay accuracy and timely delivery.
• Identify pharmacodynamic effects and early evidence of response to investigational drugs using the integrated dataset.

Requirements

• BS or MS in biology, chemistry or related field.
• 5+ years of relevant experience in Genomics on Illumina platforms (NextSeq / NovaSeq).
• Experience in ctDNA assays with Illumina TruSight Oncology (TSO500), Roche Avenio Targeted ctDNA, Qiagen QiaSeq or other gene panel methods.
• Proficiency in DNA extraction using laboratory automation (KingFisher Apex, Beckman i7/i5).
• Experience working with human primary samples in a GLP/GCP/CLIA regulated environment is highly desirable.
• Experience with basic molecular biology technologies (PCR/RT-PCR) and nucleic acid analysis techniques (Agilent Bioanalyzer, TapeStation, Nanodrop, Qubit, EnVision).
• Knowledge of basic bioinformatics and understanding how to QC NGS sequencing runs and interpret gene mutation data.
• Strong interpersonal skills and ability to communicate effectively, both written and orally.

Nice-to-haves

• Experience with programming languages such as R for data analysis.
• Ability to independently interpret, analyze, and troubleshoot experiments.

Benefits

• Competitive salary based on skills and experience.
• Potential for additional compensation such as bonuses.