Senior Scientist I, Biomolecular Interactions

$91,500 - $173,500/Yr

AbbVie - Worcester, MA

Full-time - Mid Level

Worcester, MA

Chemical Manufacturing

About the position

AbbVie's Biotherapeutics and Genetic Medicine Protein Science Group is seeking a dedicated and experienced scientist to join the Biomolecular Interaction Team. This role focuses on providing in-depth analytical and functional characterization of biopharmaceutical products, including monoclonal antibodies and antibody-like biologics. The position offers a unique opportunity to contribute significantly to various Discovery Research Therapeutic Areas and Projects in a collaborative and innovative environment.

Responsibilities

• Independently develop and execute SPR assays to generate selection criteria for antibodies and biologics.
• Evaluate and integrate protein-protein interaction technologies to support therapeutic candidate selection.
• Implement high-throughput epitope binning for monoclonal antibodies.
• Perform antibody Fc characterization studies to support regulatory submissions.
• Identify and resolve technical challenges independently and implement innovative research approaches.
• Exhibit scientific initiative and creativity in biologics characterization and screening.
• Analyze, document, and report data concisely, formulating conclusions and designing follow-on experiments.
• Provide direct mentorship and guidance to junior scientists and team members.
• Provide project updates, analyses, and advice to cross-functional teams and senior management.
• Present original work internally and at scientific conferences.

Requirements

• BS, MS, or PhD in biology, chemistry, biochemistry or related field with typically 10+ (BS), 8+ (MS) or 0+ (PhD) years of experience.
• Experience with analytical/functional characterization of biologics using SPR platforms.
• Demonstrated theoretical and practical understanding of the scientific discipline.
• Broad technical knowledge of various analytical, biophysical, and structural methods is a plus.
• Experience of high throughput biologics screening with biochemical, biophysical, and cell-based methods.
• Direct experience with biologics, monoclonal antibodies and/or protein therapeutics is a plus.
• Excellent organizational skills with the capacity to manage multiple projects and tasks simultaneously.
• Goal-oriented team player with excellent verbal and written communication skills.

Nice-to-haves

• Experience with SEC, MS, HDX-MS, X-ray crystallography, DSF, DLS methods.
• Ability to adapt to rapid changes in project priorities and timelines.

Benefits

• Paid time off (vacation, holidays, sick)
• Medical/dental/vision insurance
• 401(k)
• Short-term incentive programs