Senior Scientist I, Biomolecular Interactions

AbbVie - Worcester, MA

Full-time - Senior

Worcester, MA

Chemical Manufacturing

About the position

The Senior Scientist I in Biomolecular Interactions at AbbVie is a pivotal role within the Biotherapeutics and Genetic Medicine Protein Science Group. This position focuses on the analytical and functional characterization of biopharmaceutical products, including monoclonal antibodies and multi-specifics. The scientist will leverage high-throughput biologics screening techniques and collaborate with various therapeutic areas to drive innovative research and development efforts.

Responsibilities

• Independently develop and execute SPR assays to generate selection criteria for antibodies and biologics.
• Evaluate and integrate protein-protein interaction technologies to support therapeutic candidate selection.
• Implement high-throughput epitope binning for monoclonal antibodies and develop knowledge of antibody sequence/function relationships.
• Perform antibody Fc characterization studies to support regulatory submissions.
• Identify and resolve technical challenges independently and implement innovative research approaches.
• Exhibit scientific initiative in biologics characterization and screening to support BGM and TA projects.
• Analyze, document, and report data concisely, formulating conclusions and designing follow-on experiments.
• Provide mentorship and guidance to junior scientists and team members.
• Provide project updates and analyses to cross-functional teams and senior management.
• Present original work internally and at scientific conferences; may author or co-author scientific papers or patents.

Requirements

• BS, MS, or PhD in biology, chemistry, biochemistry or related field with typically 10+ (BS), 8+ (MS) or 0+ (PhD) years of experience.
• Experience with analytical/functional characterization of biologics using SPR platforms.
• Demonstrated understanding of the scientific discipline with the ability to learn and master innovative technologies.
• Broad technical knowledge of various analytical, biophysical, and structural methods is a plus.
• Experience in high throughput biologics screening with biochemical, biophysical, and cell-based methods.
• Direct experience with biologics, monoclonal antibodies and/or protein therapeutics is a plus.
• Excellent organizational skills to manage multiple projects and tasks simultaneously.
• Goal-oriented team player with excellent communication skills and a strong can-do attitude.

Nice-to-haves

• Broad technical knowledge of various analytical, biophysical, and structural methods such as SEC, MS, HDX-MS, X-ray crystallography, DSF, DLS.

Benefits

• Health insurance
• 401k plan
• Paid holidays
• Professional development opportunities
• Flexible scheduling