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About the position
Switch Therapeutics is seeking a dynamic scientist who has extensive experience in the analysis of oligonucleotides to support pipeline production and characterization of oligonucleotides. The successful candidate will be responsible for characterizing siRNA and other nucleic acid structural forms with multiple analytical techniques, including liquid chromatography and high-resolution mass spectrometry (HR MS). The individual will focus on developing and executing LC-MS-based assays to support lead-finding/optimization efforts. In addition, the candidate will function as part of a multi-disciplinary project team that will coordinate with scientists in cross functional areas to advance the lead molecules. In addition, this scientist will collaborate with a cross-functional team of experts to focus on the development and optimization of CASi candidates, as well as supervising and supporting junior team members. This is a full-time position reporting to the Vice President of our Chemistry team. The position requires on location work in our South San Francisco office.
Responsibilities
- Develop and optimize methods to fully characterize oligonucleotide drug substance and drug product materials, including HPLC, LCMS, ICP-MS, and all other relevant technologies.
- Oversee and execute the characterization of oligonucleotide materials from discovery and research stage through to development-stage compounds.
- Collaborate with internal and external manufacturing partners to develop robust analytical methods.
- Report at project team meetings, write analytical development reports, provide recommendations to management.
- Manage and support junior team members and assist with recruiting efforts as needed.
- Participate in multidisciplinary teams including Biology (in vitro and in vivo pharmacology), and Chemistry (production, analytical sciences, and platform chemistry groups).
- Provide periodic updates of efforts and results to senior management.
- Deliver innovative solutions using a diversity of thought and experiences.
- Ensure the quality of each delivered entity.
- Document all experimental activities and results in lab notebooks, report data with analysis of results in presentations and/or written reports to the scientific team.
Requirements
- PhD in analytical, organic, or biochemistry with a minimum of 6 years industry experience and at least 4 years of direct oligonucleotide experience for Principal Scientist.
- PhD in analytical, organic chemistry or a related discipline with a minimum of 4 years industry experience and at least 2 years of direct oligonucleotide analysis for Sr. Scientist.
- PhD in analytical, organic chemistry or a related discipline with a minimum of 1 year of direct experience in oligonucleotide analysis for Scientist.
- Previous experience with oligonucleotide analytical methods within the biotechnology or pharmaceutical industry setting is strongly preferred.
- Strong method development skills including experience with HPLC/UPLC platforms, capillary electrophoresis and mass spectrometry techniques is required.
- Previous experience with Orbitrap platform strongly preferred.
- Proficiency with Chromeleon, Xcalibur and Biopharma Finder is preferred.
- Previous experience managing project teams or direct reports within a biotechnology organization is preferred.
- A history of authoring publications and/or study reports.
- A deep commitment to working as part of teams to deliver breakthrough medicines.
- Excellent communication, organization, and time management skills and ability to work both independently and collaboratively.
Benefits
- Equity in the Company
- Discretionary annual bonus
- Full range of healthcare benefits
- 401(k) eligibility
- Various paid time off benefits, such as vacation, sick time, and parental leave
