Genesis Therapeutics - San Diego, CA
posted 6 days ago
Full-time - Senior
San Diego, CA
Publishing Industries
About the position
Genesis Therapeutics is pioneering artificial intelligence guided rational drug design to address severe unmet medical needs for patients. Our San Diego lab seeks a motivated and enthusiastic structural biologist to enhance our expertise in X-ray crystallography, cryo-electron microscopy, and structure based drug design. The successful candidate will collaborate and/or lead multidisciplinary drug discovery projects, manage CRO resources and develop structural biology strategy.
Responsibilities
- Develop and implement structural biology strategies for drug discovery programs from target evaluation to candidate nomination
- Lead and coordinate structural biology research projects, including managing CRO activities
- Guide protein-small molecule complex structures to support structure-based drug design and platform evolution
- Collaborate with other drug discovery disciplines (biology, medicinal chemistry, DPMK, software engineers, computational chemists) to drive hypothesis driven decisions and enhance the platform
- Regularly communicate and engage with project team members and management
Requirements
- PhD in crystallography, cry-EM, biophysics, or relevant structural biology degree with 8+ years of industrial drug discovery experience
- MS in structural biology with at least 14 years of industrial drug discovery experience
- Expertise in protein production, purification, X-ray crystallography and cryo-EM
- Experience across oncology and immunology targets
- Effective management of external CRO structural biology resources
- Strong understanding of molecular modeling and computational biology
- Proficiency in characterizing protein-ligand interactions using biophysical methods
