Associate Director - Structural Biology

About the position

Genesis Therapeutics is pioneering artificial intelligence guided rational drug design to address severe unmet medical needs for patients. Our San Diego lab seeks a motivated and enthusiastic structural biologist to enhance our expertise in X-ray crystallography, cryo-electron microscopy, and structure based drug design. The successful candidate will collaborate and/or lead multidisciplinary drug discovery projects, manage CRO resources and develop structural biology strategy.

Responsibilities

• Develop and implement structural biology strategies for drug discovery programs from target evaluation to candidate nomination
• Lead and coordinate structural biology research projects, including managing CRO activities
• Guide protein-small molecule complex structures to support structure-based drug design and platform evolution
• Collaborate with other drug discovery disciplines (biology, medicinal chemistry, DPMK, software engineers, computational chemists) to drive hypothesis driven decisions and enhance the platform
• Regularly communicate and engage with project team members and management

Requirements

• PhD in crystallography, cry-EM, biophysics, or relevant structural biology degree with 8+ years of industrial drug discovery experience
• MS in structural biology with at least 14 years of industrial drug discovery experience
• Expertise in protein production, purification, X-ray crystallography and cryo-EM
• Experience across oncology and immunology targets
• Effective management of external CRO structural biology resources
• Strong understanding of molecular modeling and computational biology
• Proficiency in characterizing protein-ligand interactions using biophysical methods