Johnson & Johnson-posted about 1 year ago
Full-time • Mid Level
Spring House, PA
Chemical Manufacturing

The Associate Scientist, Lentivirus Downstream Process Development at Johnson & Johnson is responsible for developing and optimizing processes for lentiviral vector production. This role involves conducting small-scale production, purification, and characterization studies to support regulatory filings and process performance qualifications. The position requires collaboration with various teams and staying updated with emerging technologies in the field.

  • Conduct small scale lentiviral vector production process development using material from mammalian cell culture.
  • Perform purification techniques including depth filtration, affinity and/or Ion exchange (IEX) chromatography, and tangential flow filtration (TFF).
  • Conduct viral vector process characterization studies to support process performance qualification (PPQ) and regulatory filing.
  • Assist in the technical transfer of processes to manufacturing sites as needed.
  • Design, execute, analyze data, and draft reports for studies.
  • Stay current with relevant literature and evaluate new emerging technologies in viral vector production.
  • Ensure data integrity through accurate and timely data capture/entry into appropriate electronic systems.
  • B.S. or master's degree in biology, Biochemistry, Bioprocess Engineering, Virology, or a related scientific field is required.
  • Minimum 1 year of experience doing protein and/or viral vector purification is required.
  • Strong interpersonal skills, with the ability to closely collaborate with scientists and external teams is required.
  • Lentivirus experience is preferred.
  • Hands-on experience with ÄKTA FPLC purification systems is highly preferred.
  • Hands-on experience with TFF systems is highly preferred.
  • Experience working with remote teams is preferred.
  • Health insurance
  • 401k
  • Paid holidays
  • Professional development opportunities
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