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Tome Biosciences - Watertown, MA
posted 3 days ago
About the position
At Tome, we are developing the next generation of programmable genomic integration technology. Our technologies allow us to insert any genetic sequence of any size at any location into any genome. We are building an exceptional team and a work environment that is diverse, innovative, rewarding, and fun. We have an opportunity to re-write the patient story, and together, we are writing a new chapter in genomic medicines. Our Analytical Team is growing! Reporting to our Senior Scientist, Mass Spectrometry, we are seeking an Associate Scientist, Mass Spectrometry to join our organization. In this role, the individual will have the opportunity to perform LC-MS analysis of oligonucleotides, mRNA, lipids, proteins, and other components of gene therapy medicines. High resolution mass spectrometry projects will involve peptide bioanalysis (quantitative focus), RNA sequencing, PK/PD and met ID. Chromatography projects will include IPRP, IEX, SEC and GC. Opportunity to contribute to the mass spec informatics platform and help build the Mass Spec and separations team will be key in this role.
Responsibilities
- Follow documented analytical methods to perform LC-MS for the analysis of synthetic oligonucleotides, proteins and other analytes
- Operate and maintain analytical instrumentation including HPLC and Mass Specs
- Document and communicate analytical results
- Contribute to development, optimization, and operationalization of new analytical methods
- Effectively collaborate within analytical team and across other functional teams
- Maintain organized electronic records of all experimental results
Requirements
- Bachelor's degree in chemistry, engineering, biology, biochemistry, or relevant degree
- 4+ years of lab experience using HPLC and Mass Spectrometry
- Must be able to prioritize work load and multi-task in a dynamic environment
- Must be organized, proactive, and work well under deadlines
- Excellent interpersonal and communication skills (both verbal and written)
- Ability to interact with internal and external contacts at all levels of management
Nice-to-haves
- Experience with any biomolecules and biomolecule Mass Spec preferred
- Experience with Orbitrap and high resolution instrumentation is preferred
