Associate Scientist - Protein Engineering

About the position

The Associate Scientist - Protein Engineering at Codexis will be a key member of the Protein Engineering group within the Research department. This role involves engineering enzymes for the ECO Synthesis™ platform, contributing to the manufacturing of pharmaceutical intermediates and Life Science workflows. The position requires collaboration across diverse teams and focuses on designing, building, and evaluating protein libraries to identify improved enzyme variants.

Responsibilities

• Generating diverse libraries of enzyme variants through various mutagenesis methods.
• Expressing recombinant protein in high-throughput (HTP) and shake flask scale.
• Assisting in developing relevant enzyme assays in HTP format.
• Executing HTP screens to evaluate enzyme performance under application-relevant conditions, using UV-Vis Spectrophotometry, CE, HPLC, GC, LC-MS or GC-MS methods to quantify relevant products.
• Managing large data sets and communicating results to a multidisciplinary team.
• Maintaining a safe and efficient workplace, following safe lab practices and organizing lab environment.
• Keeping diligent records and writing reports and SOPs.

Requirements

• BS or MS in Molecular Biology, Biochemistry, Chemical Engineering, Biotechnology or related scientific field.
• Minimum of 6 years of relevant experience in a laboratory environment.
• Knowledge and interest in molecular biology, protein biochemistry and enzymology.
• Experience with documentation, record keeping, writing SOPs and reports.

Nice-to-haves

• Knowledge of recombinant protein expression techniques within bacterial systems.
• Experience with/understanding analytical techniques.
• Familiarity/interest in lab automation equipment.

Benefits

• Medical, Dental and Vision Insurance
• Basic Life, AD&D, Short- and Long-Term Disability Insurance
• 401k with Company Match up to 4%
• Company Equity
• Generous Paid Time Off including 18 Company Holidays (with a summer and winter shutdown), Vacation, and Wellness Time
• Annual Lifestyle Account for reimbursement of fitness programs, equipment and more
• Employee Stock Purchase Program (ESPP)
• Flexible Spending Accounts (Commuter/Parking, Dependent Care & Healthcare)
• Student Debt Program (Company Contribution to Loans)
• Mental Health Wellness Program
• Subsidized onsite lunch program
• Onsite Gym Facilities
• Paid Parental Leave