Data Scientist

Massachusetts General Physicians Organization (Mgpo) - Boston, MA

Full-time - Entry Level

Remote - Boston, MA

Publishing Industries

About the position

The Data Scientist position at the Albers Lab, part of the Mass General Institute for Neurodegenerative Disease, focuses on applying computational methods to biomedical research aimed at developing new therapeutic strategies for neurodegenerative diseases. The role involves analyzing various datasets to assess disease phenotypes and pharmacological responses, collaborating with a multidisciplinary team, and standardizing bioinformatics pipelines for translational projects.

Responsibilities

• Establish and standardize bioinformatics pipelines relevant to translational projects.
• Analyze genomic, transcriptomic (scRNA/bulk RNA), and proteomic internal and external datasets.
• Further develop the DRIAD (Drug Repurposing in Alzheimer's Disease) platform by incorporating TDP43 driven cryptic exon detection/staging.
• Develop the TRIALS (Therapeutic Repurposing in ALS) platform using machine learning to create predictors of ALS disease progression.
• Provide support for federated learning efforts to emulate clinical trials using electronic health records from various regions.
• Prepare data packages for regulatory bodies, such as NIH and FDA.
• Build and process input datasets for machine-learning models.
• Write code using a collaborative version control system, ensuring proper documentation and reproducible workflows.
• Work closely with computational scientists, researchers, and physicians to design and perform analyses.
• Assist in preparing manuscripts, abstracts, and presentations for scientific meetings.
• Lead harmonization of data schema across different data ecosystems and manage data across groups.

Requirements

• Bachelor's Degree required.
• PhD in Computer Science, Bioinformatics, or related quantitative discipline is required.
• 0-2 years of experience in data science projects is required.
• Strong programming skills in R and Python are required.
• Experience with statistical analysis and databases is strongly preferred.
• Experience in multi-omics datasets is required.
• Excellent organizational and communication skills are necessary.
• Ability to work independently and take initiative is essential.
• Highly motivated and able to meet deadlines.

Nice-to-haves

• Knowledge of neuroscience is desirable.

Benefits

• Remote work possibility.
• Affirmative Action Employer commitment to diversity and inclusion.