Engineer, MSAT

Encoded Therapeutics - Morrisville, NC

Full-time - Mid Level

Morrisville, NC

Professional, Scientific, and Technical Services

About the position

Encoded Therapeutics is seeking an Engineer, MSAT to contribute to the development of innovative genetic therapies aimed at treating severe CNS disorders. This role involves working on the manufacturing processes for clinical and pre-clinical projects, particularly focusing on the ETX101 and ETX201 programs. The successful candidate will engage in a dynamic environment, collaborating across multiple projects to support the company's therapeutic pipeline.

Responsibilities

• Design, execute, and analyze small-scale studies supporting the development of ETX101 and ETX201.
• Serve as an engineer responsible for pre-clinical and clinical manufacturing for AAV projects and plasmid manufacturing, including upstream, downstream, fill finish, and drug device.
• Facilitate technology transfer of the ETX101 and ETX201 manufacturing processes to non-GMP/GMP internal and external manufacturing sites.
• Provide person-in-plant support of GMP (clinical and commercial) manufacturing as required at internal and external sites.
• Work with cross-functional teams to develop tools/templates to support tech transfer business processes.

Requirements

• B.S or M.S. in a relevant area of specialization (biochemical engineering, chemical engineering, biological sciences, chemistry, or biochemistry).
• At least 5 years of industry experience and 3 years in an MSAT/Process Development role strongly preferred.
• Extensive working knowledge of modern laboratory procedures and knowledge of cGMP is a must.
• Ability to independently design, execute, and analyze small-scale purification studies (column chromatography, tangential flow filtration) is a must.
• Must be a team player and exhibit a willingness to meet project timelines.
• Strong verbal and written skills are required as well as effective interpersonal, technical, and troubleshooting skills.
• Outstanding planning, organization, and multitasking skills.
• Experience with fill-finish operations is strongly preferred.

Benefits

• Comprehensive benefits package, including competitive employer premium contributions.
• Meaningful stock option grants.
• PTO, sick time, and holiday pay.
• Generous Parental Leave program.
• Pre-tax medical and dependent care programs.
• STD, LTD, Life and AD&D insurance.
• Professional development opportunities.
• Team-building events.
• Fully stocked kitchen.
• Fitness center.