Medical College of Wisconsin

Medical College Of Wisconsin - Milwaukee, WI

Full-time - Entry Level

Milwaukee, WI

Educational Services

About the position

The Medical College of Wisconsin (MCW) brings a synergy between the best medical education, research and patient care. Tomorrow's discoveries happen right here alongside the very people who bring those lessons to our students. Every bit of knowledge, and every advancement, provides our students with an unprecedented, collaborative learning environment, and helps improve the vitality and care of our communities. In the role of a Bioinformatics Analyst I you will be working in the Mellowes Center for Genomic Sciences and Precision Medicine. Our unique program focuses on how to interpret genetic variations that cause human diseases. We leverage multi-disciplinary approaches, including Big Genomics Data, systems biology, computational biophysics, biochemistry, and structural bioinformatics, to develop a more comprehensive and integrated understanding of the underlying mechanisms of diseases. Focusing on rare diseases, our team continues to pioneer the methods to use AI-based tools such as protein structure prediction to model the multi-protein complexes that regulate the genome. This focus links our work between genetics and the structure of chromatin (i.e., epigenetics) - to understand how genetic differences alter how the genome is regulated and dysregulated to cause a group of genetic diseases termed chromatinopathies. The successful candidate will join our productive team in chromatinopathies research. They will use our established procedures, and work with our multi-disciplinary group of computational scientists, rare disease clinicians, laboratory technicians, and faculty, to operate the workflow and team-based process that we have developed. The goal of our program is to diagnose more patients and increase the information available to interpret genetic variation. We are seeking a motivated and skilled data scientist, who will thrive in a team environment where they will work collaboratively and independently to solve rare disease cases, analyze diverse data, and synthesize it in reports to the team and academic publication.

Responsibilities

• Understands principles of biomolecular structure, molecular simulations, and the interpretation of results. Independently provides troubleshooting for data generation and processing.
• Develops, implements, and refines bioinformatic workflows and tools for analyzing and visualizing molecular simulation data.
• Runs standardized workflow for annotating protein structures with genomics data.
• Leads the analysis and writing for a portfolio of modeling projects, prioritized by the team and Director.
• Implements triaging workflow and generates reports.
• Contributes to collaborative research publications.
• Presents regular project updates at meetings with collaborators.
• Adapts bioinformatics tools, visualization packages, and annotation resources to perform research analysis independently and accurately.
• Development of automated analysis methods to assess model quality and computed features, as well as the analysis of MD simulations.

Requirements

• Strong analytical skills and working knowledge of molecular biology, biophysics, and statistics.
• Experience using tools for molecular simulation, visualization, and analysis.
• Working experience with structural bioinformatics tools and algorithms (either in command line or IDEs).
• Ability to critically read, understand, and interpret data from scientific publications.
• Organized, detail-oriented, and an effective written and verbal communicator.

Nice-to-haves

• Experience with Linux-based HPC systems.
• Experience in statistical mechanics and machine learning.

Benefits

• Outstanding Healthcare Coverage, including but not limited to Health, Vision, and Dental.
• 403B Retirement Package.
• Competitive Vacation and Paid Holidays offered.
• Tuition Reimbursement.
• Paid Parental Leave.
• Pet Insurance.
• On campus Fitness Facility, offering onsite classes.
• Additional discounted rates on items such as: Select cell phone plans, local fitness facilities, Milwaukee recreation and entertainment.