Moslehi Lab - Assistant Professional Researcher

$87,100 - $113,900/Yr

University of California - San Francisco, CA

Full-time - Entry Level

San Francisco, CA

Educational Services

About the position

The Moslehi Lab at the University of California, San Francisco is seeking an Assistant Professional Researcher to join their team. The successful candidate will work under the direct supervision of the Principal Investigator (PI) and will be responsible for designing and executing experimental studies in both in vitro and in vivo model systems. This role requires a significant degree of independence, as the researcher will analyze data obtained from these studies and prepare it for dissemination in various contexts, including publications, grant proposals, and funding reports. Dr. Moslehi, the William Grossman Distinguished Professor in Cardiology, leads the lab and has made significant contributions to the fields of cardio-oncology and cardio-immunology. His research focuses on understanding the role of the adaptive immune system in cardiovascular disease, having defined novel clinical syndromes and developed cellular and mouse models that replicate these conditions. The lab is well-funded through multiple NIH grants and additional support from philanthropy and industry, providing a robust environment for research and discovery. The candidate will be expected to possess both theoretical knowledge and hands-on skills in relevant research areas to contribute effectively to the lab's growth. There is an opportunity for the successful candidate to eventually take on a lab manager role, which would include additional administrative responsibilities alongside scientific and program management duties.

Responsibilities

• Independently design, generate, and validate novel mouse genetic alleles that selectively abolish specific functions of a family of histone acetyl reader proteins or a transcription factor important in resident fibroblast to activated myofibroblast cell state transitions.
• Independently perform assessments of gene expression (from bulk tissue and single-cells along with nascent transcription), chromatin occupancy, and chromatin accessibility (from bulk tissue and single-cells) including sample collection and processing, library preparation, multiplexed sequencing, and downstream data analysis.
• Independently assess developmental consequences of immune subsets in the myocardium.
• Independently perform standard molecular biology and biochemistry techniques (including molecular cloning, quantitative reverse transcription PCR, virus preparation and in vitro/in vivo viral transduction, Western blotting, immunoprecipitation, co-immunoprecipitation, and chromatin immunoprecipitation) as well as high-resolution microscopy (including confocal microscopy and live-cell imaging).
• Perform project management functions for large collaborative projects involving multiple laboratories, oversee the day-to-day tasks and responsibilities of a staff research associate (SRA), and assume responsibility for maintenance of a 150-cage mouse colony.

Requirements

• PhD in Biological Sciences, Bioengineering, or related fields.
• Advanced knowledge of immunology, standard molecular biology and biochemistry techniques, next-generation sequencing-based approaches to biological interrogations, and in vivo mouse modeling.
• Demonstrated ability to contribute data and technical content to grant proposals.
• Proven skills and experience in independently resolving broad problems that may arise in collection or analysis of laboratory data.
• Self-motivated with ability to work independently and as part of a team. Able to learn effectively and meet deadlines.
• Demonstrated experience and ability to collaborate effectively with all levels of staff; technical, students, faculty and administrators.
• Demonstrated effective communication and interpersonal skills.
• Demonstrated ability to communicate technical information to technical and non-technical personnel at various levels in the organization and to external research and education audiences.
• Proven ability to successfully work on multiple concurrent projects.
• Demonstrate high integrity and professionalism to work with patient data in a HIPAA-compliant and ethically responsible manner.
• Ability to effectively manage own time.

Nice-to-haves

• Advanced skills, and demonstrated experience associated with one or more of the following: performance and analysis and laboratory-based research including design, modification, and implementation of genome-wide assays to interrogate consequences of alterations in protein structure/function.
• Demonstrated ability to regularly interface with management.
• Interest and proven ability to train and guide the efforts of junior members of the team towards carrying out the broader goals of the laboratory.
• Track record of independent research.
• Completion of post-doctoral fellowship.

Benefits

• Salary commensurate with experience and training, estimated between $87,100-$113,900.