Principal Scientist, Molecular Biology, Biochemistry, Immunology, and Mass Spectrometry
California Life - South San Francisco, CA
posted 4 days ago
About the position
Calico (Calico Life Sciences LLC) is an Alphabet-founded research and development company whose mission is to harness advanced technologies and model systems to increase our understanding of the biology that controls human aging. Calico will use that knowledge to devise interventions that enable people to lead longer and healthier lives. Calico's highly innovative technology labs, its commitment to curiosity-driven discovery science, and, with academic and industry partners, its vibrant drug-development pipeline, together create an inspiring and exciting place to catalyze and enable medical breakthroughs. Calico seeks an individual experienced in mechanistic Molecular Biology, Biochemistry, Immunology, and Mass Spectrometry interested in identifying and understanding the causes of age-associated degenerative processes including inflammaging and immune aging. We are interested in applicants with demonstrated experience applying biochemical, molecular, immunological, and cell biological approaches to study the physiology of aging cells. We are seeking a scientist that can deploy advanced molecular, cellular, and immunological techniques to integrate mechanistic findings with observations made in vivo and with hypotheses derived from human data sets. The successful candidate will utilize innovative biochemical and omics technologies and have a long-term interest in understanding the pathobiology of aging and aging-related diseases, with a particular emphasis on dysregulation of organelle function, stress signaling and metabolism. Principal Scientists at Calico are expected to be independent and function well in a highly collaborative, cross-functional research environment working closely with state-of-the art technology labs, physiology, as well as data science and machine learning groups and can lead ambitious research projects. In this role, the ideal candidate would act as a scientific advisor to senior leadership and provide direction and mentorship to cross-functional research and technology team members.
Requirements
- PhD or MD/Ph.D. in biochemistry, molecular and cellular biology, neuroscience, or related field and 18+ years of post-doctoral academic or industry experience
- Strong record of originality and productivity including impactful publications
- Ability to design complex in vitro experiments that include multimodal technologies with relevance to in vivo physiology
- Data-literate and able to independently analyze complex omics data sets especially mass spectrometry lipidomics datasets
- Excellent communication skills
- Strong track record of working collaboratively with an interdisciplinary team to produce high quality results in a timely manner
- Must be willing to work onsite five days per week
Benefits
- Base salary range of $257,000 - $269,000
- Eligible for two annual cash bonuses
