Process Development Principal Scientist - Synthetic Peptides, Oligonucleotides, ADCs
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About The Position
In this role, Amgen is seeking a Process Development Principal Scientist with industry experience in the manufacturing of synthetic peptides, oligonucleotides, and/or antibody drug conjugates to join our Drug Substance Technologies - Synthetics (DSTS) group. Amgen's DSTS group within Process Development (PD) is responsible for the invention, development, characterization, and implementation of synthetic drug substance manufacturing processes and technologies to advance Amgen's innovative small molecule and hybrid portfolio. The Principal Scientist role will include supporting the development of efficient and sustainable manufacturing processes to prepare peptides, oligonucleotides, and/or antibody drug conjugates, driving technology innovation to support bio-conjugation, and providing technical expertise towards manufacturing and commercialization. The successful candidate will work with a diverse team of synthetic chemists, chemical engineers, and analytical chemists to develop sustainable and cost-effective processes for synthetic peptide, oligonucleotide, and/or antibody drug conjugate manufacturing. This role will also involve driving technology innovation in the synthesis, purification, and characterization of bio-conjugates, supporting cGMP manufacturing and technology transfer to large-scale production facilities, and developing strategies to ensure process performance through process understanding, modeling, and characterization. The Principal Scientist will guide the successful completion of project deliverables, ensure timelines are met, and work cross-functionally to deliver regulatory documents and support regulatory filings. Additionally, the candidate will serve as a technical expert and keep current in the field of peptide, oligonucleotide, and antibody drug conjugate manufacturing, while also coaching and providing career and scientific/technical advice to colleagues within the organization.
