Process Development Scientist I/II

$94,000 - $148,610/Yr

Agc Biologics - Bothell, WA

Full-time - Mid Level

Bothell, WA

1,001-5,000 employees

Chemical Manufacturing

About the position

The Process Development Scientist I/II position at AGC Biologics focuses on enhancing cell line development and upstream process development for biopharmaceuticals. The role involves designing and executing projects aimed at improving current CLD platforms, acting as a subject matter expert, and supporting the scale-up and transfer of mammalian cell culture processes to GMP manufacturing.

Responsibilities

• Design, write protocols, execute, and analyze experiments to improve the current CLD platform and evaluate new CLD technology.
• Present data to project teams in verbal and written formal reports.
• Work with clients and internal project teams in the successful completion of contract manufacturing projects.
• Take a leadership role within the department in developing and improving cell culture processes.
• Develop, coordinate, and communicate experimental plans within the department.
• Execute and manage shake flask and/or bench scale bioreactor experiments.
• Manage large data sets and provide technical guidance to others in the analysis and interpretation of data.
• Write development protocols and characterization reports.
• Coordinate activities and experiments with project management, manufacturing, purification development, and analytical development.
• Provide technical support to manufacturing during large-scale manufacturing campaigns.
• Contribute to the overall CLD lab operations and infrastructure improvements.
• Perform molecular cloning, DNA purification, transfections, cell passaging, cell imaging, monoclonality determination, cell thaw, and cryopreservation.
• Perform titer analysis by Octet or other assays as needed.
• Provide technical support in the laboratory as necessary.
• Troubleshoot process control instrumentation.
• Implement new equipment and technology.
• Provide technical and strategic planning support to business development activities.

Requirements

• An advanced degree in life science or engineering: Master's with a minimum of 8 years or Ph.D. with a minimum of 3 years of industrial experience in mammalian cell line development related to manufacturing biotherapeutics.
• Demonstrated experience in expression vector optimization, cell line engineering, media optimization, and other CLD platform improvements.
• Excellent technical writing and presentation skills.
• Ability to problem solve and troubleshoot.
• Flexibility to work both independently and in a team setting.
• Willingness to support evening or weekend work, if needed.
• Ability to lift 30 pounds and good manual dexterity to work in a laboratory environment.
• Dependable, detail-oriented, organized, and willing to perform both routine tasks and develop new skills.
• Previous supervisory, technical guidance, and leadership experience is preferred.
• Entrepreneurial/business aptitude with interest in growing a contract manufacturing business.
• Good interpersonal relationship skills required for working with clients.
• Previous experience with process validation activities and knowledge of large-scale manufacturing activities in a GMP environment.
• Experience with JMP or other statistical analysis tools would be beneficial.

Nice-to-haves

• Experience with process validation activities and knowledge of large-scale manufacturing activities in a GMP environment.
• Experience with JMP or other statistical analysis tools.

Benefits

• Highly competitive compensation package
• Friendly, collaborative culture that values personal initiative and professional achievement