Revance International - Newark, CA

posted 4 months ago

Full-time - Entry Level
Newark, CA

About the position

The Quality Control Analyst I, Analytical will be responsible for the testing of in-process, lot release, and stability samples for various commercial and clinical drug products. This role involves authoring and revising Standard Operating Procedures (SOPs), deviations, change requests (CRs), and laboratory investigation reports (LIRs). The analyst will conduct tests on samples for various parameters including Appearance, pH, UV and water content, as well as perform analytical techniques such as HPLC, ELISA, Western Blot, and SDS-PAGE as required. The position requires participation in or leading investigations, reporting, and process optimization activities, and necessitates active involvement in group and project teamwork. The Quality Control Analyst will perform routine and non-routine release, in-process, and stability testing for drug substances, drug products, and other critical reagents, ensuring compliance with current Good Manufacturing Practices (cGMP). The analyst will independently author and lead quality records such as deviations, lab investigations, corrective and preventive actions (CAPA), and change controls, ensuring thorough and timely investigations and implementation activities. Additionally, the analyst will support method development, optimization, transfer, qualification, and validation activities of analytical methods, and will be involved in equipment and software qualification and maintenance activities. The role also includes reviewing laboratory records generated in support of QC testing, providing training to laboratory analysts, and guiding junior analysts in the lab environment, including troubleshooting. The analyst will work on multiple projects to meet departmental and organizational goals and will collaborate with Manufacturing, Quality Assurance (QA), and Regulatory teams to support Chemistry, Manufacturing, and Controls (CMC) analytical deliverables.

Responsibilities

  • Perform routine and non-routine release, in-process and stability testing for drug substance, drug product, and other critical reagents and documentation under cGMP.
  • Perform Analytical assays such as HPLC (SEC, IEX, HIC, RP, affinity), ELISA, SDS-PAGE, Western Blot, Water Content, UV, Appearance, and pH.
  • Independently author and lead quality records such as Deviations, Lab Investigations, CAPA, Change Controls, including leading thorough and timely investigations and/or implementation activities.
  • Author and revise SOPs as needed.
  • Lead and/or support method development, optimization, transfer, qualification, and validation activities of analytical methods.
  • Support equipment and software qualification and maintenance activities.
  • Review laboratory records generated in support of QC testing, including procedures, methods, audit trails and other controlled documents.
  • Provide training to laboratory analysts as needed, and guide junior analysts in the lab environment, including troubleshooting.
  • Work on multiple projects to meet departmental and organization goals.
  • Work collaboratively with Manufacturing, QA and Regulatory to support CMC analytical deliverables.

Requirements

  • Master's degree; OR Bachelor's degree & 2 years' directly related experience.
  • 2-3 years in a Quality Control laboratory environment (GMP environment) within a commercial setting.
  • Hands-on experience with a wide range of analytical techniques such as ELISA, SDS-PAGE, Western Blot, Karl Fisher and HPLC (SEC, IEX, HIC, RP, affinity).
  • Experience in writing and/or authoring deviations, lab investigations, protocols, SOPs, reports, and data trending.
  • Prior experience working in method validations, method transfers, raw material and stability testing.
  • Ability to maintain data integrity, and understanding of US and international (e.g. EU, ICH, GXP) regulations.
  • Ability to manage multiple tasks and meet deadlines with a high tolerance for ambiguity; solutions oriented and able to problem-solve and identify root cause.

Benefits

  • 401(k) matching
  • Employee stock purchase plan
  • Health insurance
  • Health savings account
  • Parental leave
  • Tuition reimbursement
  • Unlimited paid time off
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