Research Scientist, Liver Disease

$108,500 - $108,500/Yr

Takeda Pharmaceutical Company - Boston, MA

Full-time - Senior

Boston, MA

Chemical Manufacturing

About the position

At Takeda, we are a forward-looking, world-class R&D organization that unlocks innovation and delivers transformative therapies to patients. By focusing R&D efforts on three therapeutic areas and other targeted investments, we push the boundaries of what is possible in order to bring life-changing therapies to patients worldwide. Join Takeda as a Research Scientist in Liver Disease Research, where you will be part of a team focused on the validation of novel targets and the evaluation of drug candidates for the treatment of chronic fibroinflammatory liver diseases. In this role, you will apply your expertise in executing in vitro studies relevant to fibroinflammatory liver disease biology and pharmacology. You will play a central role in generating key data for evaluating potential targets, mechanisms of action, and/or drug candidate efficacy and pharmacodynamics. A highly collaborative and energetic team player, you will be a self-directed learner with a keen interest in focused, fast-paced research. You will design and execute relevant target and drug candidate validation studies using contemporary methods and tools, and using a broad range of technologies, determine the mechanism of action for drug targets and candidates with appropriate controls. Your responsibilities will include implementing target-specific assays to assess target and drug activity in vitro and/or in vivo, identifying orthogonal applications of target, pathway, or platform biology in other fibroinflammatory diseases, and participating on cross-functional teams to provide technical leadership in your area of expertise. You may lead an initiative or one of a broader scope with a less-defined outcome. You will prepare technical reports, summaries, protocols, and quantitative analyses in written and/or oral form, proactively identifying complex obstacles to progress in specific areas and recommending and implementing solutions using a diverse set of resources. You will manage a wide variety of tasks, techniques, and projects, integrating these responsibilities to produce quality results with a high level of efficiency, and may act as a scientific mentor to others. Additionally, you will maintain lab equipment and supplies as needed, keep an accurate, comprehensible, concise notebook in accordance with company policy, and maintain a safe and organized lab bench. Effective communication with colleagues and presenting data to other scientific staff or cross-functional project teams will also be key aspects of your role.

Responsibilities

• Apply expertise in executing in vitro studies relevant to fibroinflammatory liver disease biology and pharmacology.
• Generate key data for evaluating potential targets, mechanism of action and/or drug candidate efficacy and pharmacodynamics.
• Design and execute relevant target and drug candidate validation studies using contemporary methods and tools.
• Determine mechanism of action for drug targets and candidates with appropriate controls using a broad range of technologies.
• Implement target-specific assays to assess target and drug activity in vitro and/or in vivo, as appropriate.
• Identify orthogonal applications of target, pathway, or platform biology in other fibroinflammatory diseases.
• Participate on cross-functional teams and provide technical leadership in area of expertise; may lead an initiative or one of a broader scope with a less-defined outcome.
• Prepare technical reports, summaries, protocols, and quantitative analyses in written and/or oral form.
• Proactively identify complex obstacles to progress in specific areas; recommend and implement solutions using a diverse set of resources.
• Manage a wide variety of tasks, techniques, and projects; integrate these responsibilities to produce quality results with a high level of efficiency; may act as a scientific mentor to others.
• Maintain lab equipment and supplies as needed.
• Maintain a safe and organized lab bench.
• Communicate with colleagues effectively.
• Present data to other scientific staff or cross-functional project team; may present data/posters to external research or scientific community.

Requirements

• PhD degree in a scientific discipline (or equivalent), or MS with 6+ years relevant experience, or BS with 8+ years relevant experience in vitro drug discovery research.
• Demonstrated ability to independently solve scientific problems using multiple, state-of-the-art technologies and approaches.
• Significant experience with drug discovery applications of cell culture including immortalized cell lines, primary cell cultures, and multicellular or organoid culture models, preferably models that recapitulate cellular cross-talk in fibroinflammatory or diseased tissues.
• Expertise in at least one of the following assay methods: ELISA, Western blot, qPCR, flow cytometry, ChIP.
• Experience and continued willingness to work with live rodents and animal tissue.
• Demonstrates exceptional project management skills and in-depth in vitro cell and molecular biology assay experience.

Benefits

• Medical insurance
• Dental insurance
• Vision insurance
• 401(k) plan with company match
• Short-term and long-term disability coverage
• Basic life insurance
• Tuition reimbursement program
• Paid volunteer time off
• Company holidays
• Well-being benefits
• Sick time accrual (up to 80 hours per year)
• Paid vacation accrual (up to 120 hours for new hires)