Gilead Sciences - Foster City, CA

posted 4 months ago

Full-time - Mid Level
Foster City, CA
Chemical Manufacturing

About the position

At Gilead, we're creating a healthier world for all people. For more than 35 years, we've tackled diseases such as HIV, viral hepatitis, COVID-19, and cancer - working relentlessly to develop therapies that help improve lives and to ensure access to these therapies across the globe. We continue to fight against the world's biggest health challenges, and our mission requires collaboration, determination, and a relentless drive to make a difference. Every member of Gilead's team plays a critical role in the discovery and development of life-changing scientific innovations. Our employees are our greatest asset as we work to achieve our bold ambitions, and we're looking for the next wave of passionate and ambitious people ready to make a direct impact. We believe every employee deserves a great leader. People Leaders are the cornerstone to the employee experience at Gilead and Kite. As a people leader now or in the future, you are the key driver in evolving our culture and creating an environment where every employee feels included, developed, and empowered to fulfill their aspirations. Join Gilead and help create possible, together. Gilead Sciences Protein Therapeutics Department has an exciting opportunity for a highly motivated Research Scientist to join the Protein Science group. In this position, the candidate will support diverse research project teams in the generation and analytical characterization of biologics molecules. He/she should have hands-on experience and in-depth knowledge of protein purification and qualification. This person will work in collaboration with research project teams to generate potential therapeutic proteins and surrogate tool molecules, aiding in the selection of lead candidates including bispecific antibodies, immunocytokines, and many other novel and complex biologics.

Responsibilities

  • Execute protein purification and qualification protocols, and perform troubleshooting when needed
  • Continuously adopt state of the art technologies to improve efficiency and/or expand capability for protein purification and qualification
  • Collaborate with therapeutic area biologists to generate proteins and advance project goals in support of large molecule therapeutic programs
  • Serve as a technical expert in research project teams, and may serve as a core team member representing Protein Therapeutics
  • Mentor and may manage junior staff

Requirements

  • Detailed scientific knowledge of protein science
  • Skilled in programming and use of AKTA Avant/Pure or BioRad Nfor protein purification
  • Extensive experience in purification of biologics molecules using techniques including affinity (Protein A/G/L, Capture Select affinity resins, Ni-NTA, etc), ion exchange, size exclusion, hydrophobic interaction chromatography, mixed-mode chromatography
  • Experienced in various protein analytical techniques such as HPLC or UHPLC, SDS-PAGE or CE-SDS, Endosafe, SEC-MALS
  • Working knowledge in construct design for therapeutics proteins and surrogate tool molecules
  • Strong analytical, communication, and organizational skills

Nice-to-haves

  • Experience in automated liquid handling systems for protein purification (e.g., Tecan) is a strong plus
  • Experience in LC-MS analysis of biologics sample is highly desired

Benefits

  • Company-sponsored medical insurance
  • Company-sponsored dental insurance
  • Company-sponsored vision insurance
  • Company-sponsored life insurance
  • Discretionary annual bonus
  • Discretionary stock-based long-term incentives
  • Paid time off
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