Bristol-Myers Squibb - Cambridge, MA
posted 5 months ago
The Scientist position in Functional Assays at Bristol Myers Squibb (BMS) is a pivotal role within the Discovery Biotherapeutics team, located in Cambridge, MA. This team is dedicated to understanding the structure and function of complex therapeutic molecules, including bispecific antibodies and antibody-drug conjugates. The primary objective is to optimize these molecules for their therapeutic potential, collaborating closely with biology and translational scientists embedded in Thematic Research Centers. The successful candidate will engage in innovative research that aims to discover and deliver first-in-class and best-in-class biotherapeutics, ultimately benefiting patients in need. In this role, the Scientist will utilize a variety of in vitro biochemical and cellular techniques to enhance the workflow of primary antibody screening and the mechanistic characterization of diverse biotherapeutic candidates. This includes the design and execution of primary screening assays and downstream functional assays that are crucial for hit selection and lead characterization. The position requires a self-motivated and detail-oriented individual who can thrive in a dynamic and supportive environment, while also being capable of independent thought and action. The Functional Assays team plays a critical role in characterizing molecules to facilitate the discovery of effective biologic candidates. The successful candidate will be expected to develop fit-for-purpose primary screening assays, explore commercial sources, and design cellular assays for functional characterization. They will also be responsible for characterizing protein reagents using advanced techniques such as flow cytometry and biolayer interferometry, and will serve as a functional assay representative on multidisciplinary project teams. Data analysis and presentation to stakeholders, along with meticulous documentation of experiments in an Electronic Notebook, are essential components of this role.