Invitro Cell Research - Leonia, NJ
posted 6 months ago
In this role at InVitro Cell Research, LLC, you will be part of the Functional Genomics program, which focuses on understanding the roles of genetic variants that are classified as 'of unknown significance', 'possibly damaging', and 'likely deleterious' in relation to human health and disease. Your primary responsibility will involve conducting in-depth research on suspected pathogenic single nucleotide polymorphisms (SNPs) and other genetic variants to ascertain their potential deleterious effects on protein, cellular, and systems-level functions. This will include a comprehensive analysis that traces the impact of these SNPs from the gene level through to phenotypic outcomes. Your work will encompass a variety of tasks, including investigating the functional implications of specific SNPs on protein or cellular functions. This will involve a detailed examination of the pathways from RNA to protein, and from cellular interactions to broader systems-level analyses. You will also engage with known disease-associated SNPs and variants of uncertain significance (VUSs) within the context of various human primary and induced pluripotent stem cell (iPSC)-derived cell types. Additionally, you will be responsible for project management of outsourced work with Contract Research Organizations (CROs) to enhance your productivity and ensure that project timelines and objectives are met. Collaboration with fellow scientists at ICR will be essential as you work together to unravel complex medical mysteries related to human genetics and disease.