Scientist I/II, Biologics Upstream Process Development

Asimov - Boston, MA

Full-time - Entry Level

Boston, MA

Ambulatory Health Care Services

About the position

As a Scientist I/II in Biologics Upstream Process Development at Asimov, you will play a crucial role in advancing biopharmaceutical and gene therapy processes. This position involves hands-on bioprocess engineering, experimental design, and collaboration with various teams to optimize workflows and scale processes. You will be a technical expert, coordinating projects and interfacing with external partners to drive innovation in synthetic biology.

Responsibilities

• Conduct bioprocess engineering for biologics and design experimental approaches to improve workflows.
• Apply scaling principles to upstream processing and coordinate interdepartmental project efforts.
• Serve as a technical subject matter expert (SME) in upstream process development for internal and external projects.
• Represent the process development team on cross-functional projects, making decisions for process development activities.
• Collaborate with strategic alliance and commercial teams to technology transfer developed upstream processes to external partners.
• Work with the process modeling team to develop robust predictive models using DOE approaches and machine learning algorithms.
• Collaborate with the software team to develop integrated data platforms for streamlined data analysis.
• Author, review, and approve process development reports and technology transfer protocols.
• Organize and document experiments and data in an electronic lab notebook.
• Perform downstream processing/purification and product quality assessment with analytical tools when needed.

Requirements

• PhD in Biological Engineering, Chemical Engineering, Cell Biology, Molecular Biology, or a related field with 0-2 years of relevant hands-on experience in bioprocessing.
• Alternatively, a MS with minimum of 4 years or a Bachelor's with minimum 6 years of hands-on industry experience.
• Experience in mammalian (CHO) process development.
• Experience with LVV and AAV process development is beneficial but not essential.
• Experience with '-omics' (i.e., metabolomics, proteomics, glycomics) and its impact on drug product quality attributes is a plus.
• Experience with Ambr15, Ambr250, and/or benchtop scale fed-batch bioreactor processes.
• Analytical development and downstream purification experience (i.e., TFF) is highly preferable.
• Experience in technology transfer of manufacturing processes and CMC filing in the pharmaceutical industry.
• Expertise in spreadsheets such as Google Sheets or Excel, and ideally Spotfire, Google Apps Script (JavaScript), and/or BigQuery.

Nice-to-haves

• Experience with perfusion processes is welcomed but not required.
• Familiarity with implementing algorithm-based design approaches is a plus.

Benefits

• Full-time position with competitive salary.
• Opportunity to work in a forward-thinking synthetic biology startup.
• Collaborative and diverse company culture.