Vaxcyte - San Carlos, CA

posted 4 months ago

Full-time - Mid Level
San Carlos, CA
Professional, Scientific, and Technical Services

About the position

Vaxcyte, Inc. is seeking a Scientist II in Research Analytical Development to join our mission of protecting humankind through innovative vaccine solutions. As a clinical-stage vaccine innovation company, we are dedicated to engineering high-fidelity vaccines aimed at combating bacterial diseases that pose significant health risks. The successful candidate will play a crucial role in the design, execution, and interpretation of assays that analyze our drug substances and intermediates, which include proteins, polysaccharides, and protein-polysaccharide conjugates. This position is integral to our efforts in developing vaccines for serious bacterial infections such as invasive pneumococcal disease, Group A Strep, periodontitis, and Shigella. In this role, you will be responsible for conducting various assays, including microplate assays (both colorimetric and enzyme-based), HPLC-SEC, RP-HPLC, CE, and iCIEF. You will assist in the analytical method development of new assays to support novel targets, ensuring that all experiments are documented accurately and comprehensively. Your ability to summarize data and communicate findings to the analytical team will be essential for advancing our research objectives. Additionally, you will support daily lab operations, manage sample inventory, and oversee sample shipments, all while fostering a collaborative team environment. As a Scientist II, you will also provide technical direction, mentorship, and coaching to junior team members, ensuring that all tasks are completed with high quality and in a timely manner. Your contributions will be guided by our core values of aiming high, leading with heart, rethinking convention, and modeling excellence, which are fundamental to our collaborative and innovative culture.

Responsibilities

  • Assist with design, execution, and interpretation of assays to analyze drug substances and intermediates.
  • Conduct microplate assays, both colorimetric (BCA, PicoGreen) and enzyme-based assays (ELISA/MSD).
  • Perform HPLC-SEC and RP-HPLC, with favorable experience in ChemStation.
  • Utilize CE and iCIEF techniques in analytical processes.
  • Assist in analytical method development of new assays to support novel targets.
  • Maintain accurate and detailed records of experiments.
  • Summarize data and communicate findings to the analytical team.
  • Support daily lab operations, including sample inventory and sample shipment.
  • Work within a team environment to support team objectives.
  • Provide technical direction, mentorship, and coaching to junior team members.
  • Complete assigned tasks with high quality and in a timely manner.

Requirements

  • PhD in Chemistry, Analytical Chemistry, Biochemistry, or related field with 4+ years relevant industry experience; MS with 8+ years or BS with 12+ years of industry experience in Pharma/Biotech industry required.
  • Experience with analytical development for biologics or small molecules; experience with vaccines, carbohydrates, or conjugates is a plus.
  • Familiarity with techniques including U/HPLC/UV/FLD/RI, SEC-MALS, DLS, CE, SDS-PAGE, mass spectrometry, and other analytical technologies as applied to conjugate vaccine development.
  • Understanding of basic principles of analytical method development, validation, and qualification concepts.
  • Ability to critically review and assess analytical methods under development and troubleshoot issues during method development.
  • Attention to detail and excellent skills in record keeping and documentation.
  • Strong critical thinking and data analysis skills.
  • Ability to work with minimum supervision in a collaborative environment.
  • Good interpersonal skills with effective verbal and written communication.

Benefits

  • Competitive salary package
  • Comprehensive benefits
  • Equity component
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