Scientist, Immunology, Discovery Research

Generation Bio - Cambridge, MA

Full-time - Mid Level

Cambridge, MA

101-250 employees

Professional, Scientific, and Technical Services

About the position

Generation Bio is seeking an energetic and highly motivated Scientist to join the Immunology team within the Discovery Research group. This position is crucial for the development and evaluation of the cell-targeted lipid nanoparticle (ctLNP) delivery platform, focusing on in vitro assays that assess interactions between ctLNPs and immune cells. The role requires a strong background in cell-based assays and aims to support early program development for various indications.

Responsibilities

• Contribute to the design, optimization and execution of assays to assess ctLNP interactions with primary immune cells
• Work with Preclinical Group to evaluate novel ctLNPs and target biologies for new platform technologies
• Perform a range of biochemical techniques such as ELISA, MSD, qPCR and flow cytometry to characterize protein and RNA expression and function
• Design experiments, analyze data and interpret results
• Summarize work in written reports and oral presentations
• Maintain accurate and up-to-date laboratory records

Requirements

• Experience in the fields of immunology or cell biology (or related)
• PhD, MS with a minimum of 6 years of related experience, or BS with a minimum of 8 years of related experience, industry experience preferred
• Demonstrated leadership and hands-on experience in primary immune cell assay development and execution
• Experience isolating and culturing primary immune cells, such as T cells and B cells from human and/or mouse required
• Experience with T cell assays (such as T cell activation and differentiation)
• Knowledge of flow cytometry and multi-color panel design strongly desired
• Experience with QPCR, western blot techniques, ELISAs, etc a plus
• Ability to work cross-functionally in a dynamic matrixed environment
• Ability to multi-task to support multiple projects across platform discovery organization
• Organized, excellent communication skills, collaborative mindset

Nice-to-haves

• Experience with western blot techniques
• Experience with ELISAs