Senior Bioinformatic Research Scientist/Bioinformatic Research Scientist -Kellogg Lab

$104,000 - $186,160/Yr

St. Jude Children's Research Hospital - Memphis, TN

Full-time - Mid Level

Memphis, TN

Hospitals

About the position

As part of the Structural Biology Department at St. Jude Children's Research Hospital, the Kellogg lab seeks a talented computational biologist who is looking to make high-impact contributions on exciting challenges at the scientific frontier of genome-editing. The Kellogg lab uses cutting-edge genetics, cryo-electron microscopy, machine learning, and protein design to develop novel genome-editing tools. Located on the 6th floor of the new Inspiration4 Advanced Research Center (opened in 2021), the Kellogg lab leads the forefront of research in understanding the biology of CRISPR-associated transposons and is well supported by the NIH, Pew Biomedical Foundation, and the Cystic Fibrosis Foundation to develop novel approaches to engineer programmable transposons for clinical gene replacement therapy. The Kellogg lab is a highly interdisciplinary scientific environment, routinely working with generously supported St. Jude research core facilities: Cryo-EM Center, the Protein Technology Center, the Single-Molecule Imaging Center, the Center for Advanced Genome Editing, and the Cell & Tissue Imaging Center. The Kellogg lab is a scientifically enriching environment with regular CRISPR supergroup discussions with Dr. Shengdar Tsai. In addition, the Kellogg lab is an active member of RosettaCommons and the Rosetta community. In this position, the candidate will be exposed to multiple, cutting-edge techniques spanning cryo-electron microscopy, computational protein design, machine learning, and advanced genomics in a world-class research environment aimed at advancing cures for genetic disorders.

Responsibilities

• Develop new research directions under close mentorship of Dr. Kellogg.
• Stay up to date with latest CRISPR and protein engineering literature, conduct regular literature reviews in collaboration with Dr. Kellogg and other Kellogg lab members.
• Collaborate with other Kellogg lab members to design & clone large DNA libraries using state of the art machine learning methods.
• Map phylogenetic relationships of CRISPR-associated systems to map functional interactions.
• Develop innovative sequence profile machine-learning based protein design pipelines in collaboration with Dr. Kellogg.
• Collaborate with Kellogg lab members to develop novel tools/assays to collectively advance lab research goals.
• Mentor Kellogg lab members in executing internally developed computational analyses and pipelines.
• Prepare manuscripts and present research at relevant conferences, including but not limited to: CRISPR, genome-engineering, or protein design conferences.

Requirements

• Bachelor's degree in bioinformatics, cheminformatics, statistics/computer science (with a background in biological sciences or chemistry) or related field.
• Master's degree or PhD preferred.
• Minimum Requirement: Bachelor's degree with 7+ years of relevant post-degree work in bioinformatics, cheminformatics, statistics/computer science (with a background in biological sciences or chemistry).
• Experience Exception: Master's degree with 5+ years of relevant post-degree experience (OR) PhD with 2+ years of relevant post-degree experience.
• Significant experience in at least one programming or scripting language and at least one statistical package, with R preferred.

Nice-to-haves

• Experience in metagenomic mining.
• Experience in reconstructing evolutionary trajectories.
• Experience in protein structure prediction.
• Experience in computational protein design.

Benefits

• Competitive compensation packages commensurate with experience.
• Excellent healthcare plans with zero to low health premium costs.
• Generous retirement benefits with contributions from St. Jude.
• Onsite health clinic, pharmacy, and exercise facilities.
• Paid parental leave and adoption assistance.
• Immigration Services.
• Tuition Reimbursement.