Senior Computational Research Scientist

$104,000 - $186,160/Yr

St. Jude Children's Research Hospital - Memphis, TN

Full-time - Senior

Onsite - Memphis, TN

Hospitals

About the position

The Abraham Lab at St. Jude Children's Research Hospital is seeking a Senior Computational Research Scientist to contribute to groundbreaking research in pediatric cancers. This role involves studying the intricate relationships between the genome and nuclear organizations, focusing on how these factors influence gene expression in both healthy and diseased cells. The lab is recognized for its advanced computational infrastructure and analytical pipelines, providing an environment where your work will have a direct impact on the care of pediatric cancer patients. As a Senior Computational Research Scientist, you will analyze data from various second- and third-generation sequencing applications, delving into human gene regulatory biology. The Abraham Lab is particularly interested in understanding gene expression-regulation mechanisms, especially concerning enhancers and super-enhancers. Your responsibilities will include developing tools and frameworks for analyzing high-throughput sequencing data, building analytical software pipelines, and addressing biological questions related to gene regulation in genome-wide datasets. This includes working with applied sequencing experiments such as CUT&RUN-Seq, RNA-Seq, and Hi-ChIP, as well as some single-cell experiments. The successful candidate will be a key member of a multidisciplinary team, collaborating with researchers both within and outside the lab. Strong communication and interpersonal skills are essential, as you will be expected to work closely with other scientists and contribute to collaborative research efforts. Additionally, a solid understanding of gene expression mechanisms, including transcription factors and genome structure, is preferred. The Department of Computational Biology offers access to high-performance computing clusters, cloud computing environments, and innovative visualization tools, along with mentorship from experienced faculty scientists. We encourage high-profile publications to share our discoveries with the broader scientific community.

Responsibilities

• Analyze data generated from second- and third-generation sequencing applications.
• Develop tools and frameworks for analyzing high-throughput sequencing data.
• Build analytical software pipelines to address biological questions about gene regulation.
• Collaborate with multidisciplinary teams to study gene expression regulation in pediatric cancer cells.
• Manage large datasets and ensure effective data analysis and interpretation.
• Communicate research findings clearly and succinctly to team members and stakeholders.

Requirements

• Bachelor's degree in Bioinformatics, Molecular Biology, Biochemistry, Computer Science, or related field.
• 7+ years of relevant experience, or 5+ years with a Master's degree, or 2+ years with a PhD.
• Experience building and deploying analysis pipelines using genomic analysis toolkits (e.g., bedtools, samtools, HiCPro).
• Strong understanding of gene expression mechanisms, including transcription factors and enhancers.
• Proven performance in computational research techniques and processes.

Nice-to-haves

• Experience managing large datasets.
• Ability to create clear figures using R.
• Prior experience in collaborative research environments.

Benefits

• Comprehensive health insurance coverage.
• 401(k) retirement savings plan.
• Tuition reimbursement for further education.
• Flexible scheduling options.
• Professional development opportunities.