Senior Research Associate, Cell Engager Therapies In Vivo Pharmacologist

Takeda Pharmaceutical Company - Boston, MA

Full-time - Mid Level

Boston, MA

Chemical Manufacturing

About the position

The Senior Research Associate, Cell Engager Therapies In Vivo Pharmacologist at Takeda is a pivotal role focused on the discovery and development of novel therapeutics in the T cell engager space. This fully lab-based position involves working closely with the in-vivo lead to conduct critical path activities, including the development of in vivo models for cancer, target validation, and assessing therapeutic concepts. The role requires strong expertise in in vivo pharmacology and aims to advance development candidates to IND while collaborating effectively within the Oncology Drug Discovery Unit.

Responsibilities

• Development of animal models to test the biological efficacy of therapeutic agents for oncology indications.
• Design and execute in vivo efficacy models in xenograft and PDX models.
• Participate in analysis of in vivo studies to help establish PK/PD/efficacy relationships.
• Execute experiments with minimum supervision and deliver comprehensive high-quality data sets to enable decision making.
• Ability to multi-task effectively and prioritize workload.
• Interpret results of complex experiments.
• Prepares and presents comprehensive technical or project reports and formal presentations.
• Maintain laboratory notebooks and follow laboratory practices in compliance.
• Demonstrate in-depth technical in vivo knowledge.
• Clarify requests and provide suggestions and put data into context especially in context of study design and quality of data.
• Be an in vivo SME on projects providing scientific feedback to advance programs in a matrixed environment.
• Provide information to project teams to influence direction, align with departmental goals and/or business.
• Conduct scientific presentations to internal audiences.
• Collaborate with others across sites, and act as scientific resource for in vitro pharmacology.
• Strive towards expanding scientific knowledge in immunology.
• Receive high level instructions on work; determine methods on new assignments; demonstrated greater independence; may manage interns.

Requirements

• MS with 1+ years' experience, or BS with 3+ years' of research experience in lab setting working with animals.
• Experience in industry required, in animal facilities.
• Proficiency with in vivo efficacy rodent models, including mouse syngeneic, xenograft and PDX models.
• Experimental skills, including mammalian tissue culture, in vivo model development, drug administration by multiple routes (IV, SQ, IP, PO, RO), and blood/tissue collection.
• Imaging experience is highly desirable.
• Experience culturing and maintaining human tumor cell lines and primary human cells, preferably T cells, with best practices in tissue culture is critical.
• Hands-on basic experience with multi-color flow cytometry, ELISA, MSD and other standard cell based and non-cell based biochemical assays is desired.
• Use of scientific databases and application for data management and data analysis (Graph Pad Prism, Soft Max Pro, Office 365, FlowJo etc).
• Excellent team player with a can-do attitude with an ability to thrive in a dynamic 'biotech-like' environment and work in cross-functional project teams.
• Self-motivated, collaborative with excellent time management and organizational skills.

Benefits

• Medical insurance
• Dental insurance
• Vision insurance
• 401(k) plan with company match
• Short-term and long-term disability coverage
• Basic life insurance
• Tuition reimbursement program
• Paid volunteer time off
• Company holidays
• Well-being benefits
• Sick time
• Paid vacation