Senior Scientist, Analytical Development

About the position

Sutro Biopharma, Inc. is looking for a Scientist to join our Analytical Development group to support mass spectrometry and chromatography assay development for monoclonal antibodies, bispecific antibodies, cytokines, and antibody drug conjugates. The role involves developing new chromatography assays for characterization of recombinant proteins and conjugates, performing testing to support upstream/downstream development, formulation development, and manufacturing. The Scientist will qualify assays, support technology transfer to Sutro QC and contract testing laboratories, and author and review SOPs, protocols, and technical reports. Collaboration within Analytical Development, other functional areas, external partners, and CMOs is essential. The position may involve directing multidisciplinary project teams or performing as project lead, with cross-functional interactions with senior leaders in contributing and executing goals. The Scientist will also present data to senior managers and peers as a recognized leader in their field.

Responsibilities

• Develop new chromatography assays for characterization of recombinant proteins and conjugates.
• Perform testing to support upstream/downstream development, formulation development and manufacturing.
• Qualify assays, support technology transfer to Sutro QC and contract testing laboratories.
• Author and review SOPs, protocols and technical reports.
• Work collaboratively within Analytical Development, other functional areas, external partners and CMOs.
• Perform routine maintenance and troubleshoot mass spectrometers and HPLCs.
• May direct multidisciplinary project teams, or perform as project lead.
• Cross functional interactions with senior leaders in contributing and executing goals.
• Presents data to senior managers and peers as a recognized leader in their field.

Requirements

• PhD in analytical chemistry, biochemistry, molecular biology or related scientific field and 7+ years of industry experience in the characterization of large molecule biologics is required OR BS/MS in analytical chemistry, biochemistry, molecular biology or related scientific field and 15+ years of industry experience in the characterization of large molecule biologics is required.
• Thorough understanding of protein separation methods combined with the experience in developing assays is essential.
• Expertise in operation and maintenance of HPLCs is highly preferred.
• Knowledge of additional analytical assays such as icIEF, capillary electrophoresis and activity assays is desirable.
• Experience with automated liquid handlers is desirable.
• Demonstrated leadership ability, including a commitment to mentorship and development of personnel.
• Flexibility to work on multiple projects in a fast-paced environment is essential.
• Good communication skills are essential.
• Demonstrated track record of execution and collaboration, with a focus on analytical methods using chromatography or other separation techniques.

Benefits

• 401k
• health_insurance
• dental_insurance
• vision_insurance
• paid_holidays
• paid_volunteer_time
• tuition_reimbursement
• professional_development
• flexible_scheduling