Senior Scientist I/II - Genome Editing Technology

Mammoth Biosciences - Brisbane, CA

Full-time - Senior

Brisbane, CA

Computer and Electronic Product Manufacturing

About the position

Mammoth's Editing Technologies team is hiring a Sr. Scientist I/II to play a lead role in the development of a next-generation genome editing platform. The successful candidate will optimize the platform technology for efficacy and specificity in mammalian cells to enable in vivo editing of various therapeutic targets. This is a fantastic opportunity to impact human health by making CRISPR tools that cure genetic disease. The role involves planning, designing, and executing experiments for CRISPR tool development projects, as well as designing and producing DNA and RNA-based reagents for genome editing experiments in human cells. The candidate will also contribute creatively to seed innovation projects through literature review and shape execution tactics, provide instruction to junior team members, document experiments in electronic laboratory notebooks, present experimental results at internal meetings, and disclose inventions to the IP team for patenting. Other duties may be assigned as necessary.

Responsibilities

• Plan, design and execute experiments for CRISPR tool development projects
• Design and produce DNA and RNA-based reagents for genome editing experiments in human cells
• Contribute creatively to seed innovation projects through literature review and shape execution tactics
• Provide instruction to junior team members
• Document experiments in electronic laboratory notebooks
• Present experimental results at internal meetings
• Disclose inventions to the IP team for patenting
• Other duties as assigned

Requirements

• PhD in Molecular Biology, Biochemistry, Biomolecular Engineering or a related discipline; +3 years of relevant professional experience in industry or academia, following completion of PhD
• At least 1 year of experience developing novel CRISPR tools for gene editing in mammalian cells
• Expertise in NGS assays and flow cytometry as readouts for gene editing
• Experience in optimizing RNA and DNA transfections of mammalian cells in a high-throughput setting

Nice-to-haves

• Experience with reverse transcriptase (RT) editing
• Experience in developing new assays to assess gene editing outcomes in both replicating and non-replicating cell types
• Experience designing and implementing directed evolution approaches for gene editing improvements
• Experience managing junior staff
• Working proficiency with common bioinformatics tools (Benchling, JMP, SQL, R, Python)

Benefits

• Company-paid health/vision/dental benefits
• Unlimited vacation and generous sick time
• Company-sponsored meals and snacks
• Wellness, caregiver and ergonomics, mental health and education benefits
• 401(k) with company matching