Senior Scientist, Preclinical Translation

About the position

Seismic is determined to help patients with unmet need by integrating machine learning, structural biology, protein engineering, and translational immunology to generate clinic-ready medicines. At our core, we are focused on phenomenal science, supportive culture, a diverse team, and patient-centric goals. Seismic has the tools, skills, ideas and people to make this a reality. We have an exciting opportunity for an experienced and motivated Senior Scientist to help drive novel immunotherapy programs. The candidate must be independent, goal oriented, flexible, and able to work efficiently across multiple projects. We are searching for enthusiastic, and innovative individuals with a deep scientific background in drug metabolism and pharmacokinetics (DMPK) who thrive in a fast-paced, entrepreneurial environment.

Responsibilities

• Work closely with project team leads to help design PK/PD studies and lead DMPK efforts to optimize molecules utilizing in vitro, in vivo, and in silico methods and models.
• Provide scientific leadership in the discovery of large molecule drug candidates by integrating DMPK strategy to progress drug discovery project.
• Work closely with CROs and external stakeholders for all DMPK related activities.
• Help plan and analyze in vitro & in vivo experiments, as well as effectively communicate results to peers and senior leadership.
• Make independent decisions related to day-to-day experimental activities.

Requirements

• Ph.D. with 5+ years, MSc with 12+ years or BSc with 15+ years of relevant experience.
• Excellent understanding of ADME principals with knowledge of PK/PD modeling of large molecules.
• Previous experience working with antibodies and Fc fusion proteins.
• Knowledge of bioassay development principles and data interpretation is preferred.
• Understanding of immunology, immunotherapy and autoimmunity is preferred.
• Demonstrated ability to organize and clearly communicate complex data sets to peers and senior leadership.
• Scientifically rigorous but comfortable taking calculated risks with imperfect knowledge.
• Ability to work within a team, excellent verbal and written communication and interpersonal skills.
• Self-motivated, conscientious, and passionate about improving patients' lives.

Nice-to-haves

• Knowledge of bioassay development principles and data interpretation.
• Understanding of immunology, immunotherapy and autoimmunity.

Benefits

• Positive and supportive workplace environment and culture.