Senior Scientist, Translational Genomics, Oncology R&D

AstraZeneca - Gaithersburg, MD

Full-time - Senior

Gaithersburg, MD

1,001-5,000 employees

Chemical Manufacturing

About the position

The Senior Scientist in Translational Genomics at AstraZeneca will play a crucial role in the Oncology R&D team, focusing on biomarker studies and precision oncology. This position involves leveraging advanced genomic technologies, particularly Next Generation Sequencing (NGS), to support oncology project teams in matching patients with the appropriate treatments. The role encompasses laboratory work, data analysis, and collaboration with various stakeholders to ensure high-quality biomarker data generation and validation.

Responsibilities

• Perform work in a genomics lab, including planning, designing, and executing experimental work, and documenting and communicating results to appropriate partners.
• Deliver genomic information to AZ project teams and other partners using NGS and other leading-edge technologies, as well as focused informatic analyses when needed.
• Develop and maintain internal genomics lab capability with a focus on DNA/RNA purification/quantification/QC, gene enrichment, library construction through DNA sequencing (Illumina NovaSeq), and laboratory automation development.
• Involve in data analysis/QC, troubleshooting, interpretation of results, and communication back to project teams.
• Conceptualize, develop, and execute evaluations of platforms, vendors, and emerging technologies of clinical and translational utility.
• Provide technical advice and genomic/biomarker consultation to internal and external partners.
• Deliver biomarker assays and genomic/molecular profiling datasets using sample management software, a LIMS system, Jira, electronic lab notebooks, and written project reports.
• Work effectively with Translational Medicine Leads to consult on technologies, set expectations and timelines, develop project biomarker plans, and use fit-for-purpose platforms and technical approaches.
• Be accountable for high-quality biomarker data generation, validation, and results/report delivery in a timely manner.
• Lead lab-based biomarker identification focused on project needs to deliver clinically qualified biomarkers.
• Identify exploratory biomarkers relevant for drug response/resistance, patient stratification, and disease progression.
• Ensure that all nominated biomarkers are fit for purpose in the clinical environment.
• Collaborate with diagnostic, clinical, and regulatory partners to develop companion diagnostics.
• Maintain appropriate documentation for biomarker work, comply with internal and external requirements, assist in preparation of regulatory documents, and participate in external presentation of results and peer-reviewed journal publications.
• Leverage external partners for high-throughput sequencing, technology development, and other advanced genetics/genomics approaches.

Requirements

• BS in relevant scientific subject area with 3 to 5 years related experience
• Experience with Next Generation Sequencing is required
• Experience working with clinical oncology samples is required
• Experience with Beckman i7 robotic platforms including programming of new scripts and troubleshooting script errors are required
• Experience with python, bio-turing and other informatic software packages
• Strong laboratory and analytical skills
• Excellent oral and written communication skills, with clear documentation of work performed and ability to describe and understand its importance
• Excellent problem-solving skills with clear understanding of the balance of innovation, smart risks, and project delivery
• Strong organizational and planning skills
• Strong interpersonal skills and ability to multi-task project work

Nice-to-haves

• Relevant industry experience is a plus

Benefits

• Competitive remuneration and benefits
• Market driven base salary
• Bonus and long term incentive
• Generous paid time off program
• Comprehensive benefits package