Sr. Scientist, Discovery Oncology

1556 Merck Research Laboratories Massachusetts, LLC - Boston, MA

Full-time - Mid Level

Onsite - Boston, MA

About the position

The Senior Scientist in Discovery Oncology will play a crucial role in cancer drug discovery, focusing on innovative research and collaboration across various scientific disciplines. This position involves designing and executing laboratory experiments to support drug discovery programs, with an emphasis on translating breakthrough science into effective cancer therapies. The successful candidate will contribute to a team dedicated to improving the lives of cancer patients through innovative therapeutic solutions.

Responsibilities

• Conduct cancer research that spans multiple therapeutic modalities, target validation, OMICS profiling, and mechanistic studies.
• Independently design and conduct assays, interpret, and report high-quality data to support cancer drug discovery programs.
• Collaborate with colleagues in different departments, including Discovery Oncology, Pharmacology, Chemistry, Biologics, Data Sciences, and Clinical Development to initiate and execute new drug discovery programs.
• Monitor, review, and critically interpret published work to guide internal research.

Requirements

• Ph.D. in cell and molecular biology or related field with 0-5 years of experience.
• Extensive wet lab experience in cancer biology.
• Hands-on expertise in molecular and cell biology techniques such as cloning, Western blot, RT-PCR, multi-color flow cytometry, and ELISA/MesoScale Discovery.
• Hands-on expertise in multiple methods of genetic perturbation (siRNA, shRNA, CRISPR using lentivirus and RNPs, inducible systems).
• Experience with model and assay development.
• Demonstrated ability to work independently to design and perform key experiments, interpret data, troubleshoot, and suggest next steps.
• Evidence of successful collaboration that demonstrates the ability to work and thrive in a team environment.
• Excellent oral and written communication skills.
• Proven record of innovative thinking to propose and champion new ideas and solve problems.

Benefits

• Hybrid work model with three days on-site per week and one remote working day.
• Commitment to inclusion and diversity in the workplace.
• Opportunities for professional development and collaboration across disciplines.