Translational Research Scientist

$170,560 - $170,560/Yr

Spectraforce Technologies - South San Francisco, CA

posted 6 months ago

Full-time - Entry Level
South San Francisco, CA
Administrative and Support Services

About the position

The Translational Research Scientist position is a critical role within the Molecular Profiling group, focusing on gene expression profiling to support basic research, preclinical and development activities, and translational biomarker work. The successful candidate will engage in a variety of molecular biology techniques, particularly utilizing next-generation sequencing (NGS) and quantitative PCR (qPCR) technologies. This role requires a strong foundation in molecular biology, as well as the ability to work independently and collaboratively within a team environment. In this position, the scientist will be responsible for performing RNA and DNA isolation from various tissues and cells, including human, non-human primate, and rodent samples. The role involves targeted gene expression profiling using systems such as NanoString and other RT-qPCR platforms, as well as library preparation and quality control of samples for NGS platforms. The scientist will also be expected to operate Illumina sequencing instruments, specifically the MiSeq and NovaSeq platforms, and present relevant data and results to the team. The first three months of the role will focus on training and assessing the candidate's capabilities to work independently. The position is primarily lab-based, with approximately 70-80% of the time spent in the lab and 20-30% dedicated to data analysis and quality checks. The ideal candidate will possess excellent organizational and time management skills, be able to multitask effectively, and have a positive attitude towards collaboration and teamwork.

Responsibilities

  • Perform RNA/DNA isolation from various tissues/cells from human, non-human primate, and rodents.
  • Conduct targeted gene expression profiling using NanoString or other RT-qPCR systems.
  • Prepare libraries and perform quality control of samples for use with NGS platforms.
  • Execute NGS sequencing on Illumina MiSeq and NovaSeq platforms.
  • Analyze data and present relevant results to the team.

Requirements

  • B.S/B.A/M.S/PHD in biology, chemistry, biochemistry, or molecular biology.
  • B.S/B.S with minimum 5+ years' experience; Masters with 3+ years'; PHD with 1-2 years' of relevant work experience in industry or academia.
  • Knowledge in molecular biology techniques, including RNA/DNA isolation and NGS library preparation.
  • Experience with RNA/DNA QC platforms such as the Fragment analyzer, Agilent Bioanalyzer or Tapestation.
  • Experience with RT-qPCR methods and platforms.
  • Familiarity with NGS platforms, specifically Illumina MiSeq and Novaseq.
  • Ability to troubleshoot new protocol methods centric to NGS platforms.
  • Good communication skills and comfort working in a team environment.
  • Ability to work independently and with minimal supervision.
  • Strong organization and time management skills.

Nice-to-haves

  • Experience with liquid automation for sample RNA/DNA isolation and NGS library prep.
  • Experience with multi-omics NGS platforms, low sorted cell populations, and/or single-cell RNAseq.
  • Experience with NGS analysis data visualization software such as Cell Ranger or BioTuring.
  • Familiarity with computer software: Illumina BaseSpace, Omicsoft, TIBCO Spotfire, Graphpad Prism, Ingenuity Pathway Analysis, Geneious.

Benefits

  • ACA compliant health benefits
  • Dental insurance
  • Vision insurance
  • Accident insurance
  • Critical illness insurance
  • Voluntary life insurance
  • Hospital indemnity insurance
  • Commuter benefits
  • 401K plan with matching
  • Referral bonus program
  • Paid sick leave when required by law
  • Unpaid leave
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